Is MRKH syndrome caused by intrauterine blood exchange between sex-discordant twins?

MRKH syndrome caused by Intrauterine Placental Transfusion between sex-discordant twins?

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON28058

Enrollment

Registered

2016-07-08

Start date

2017-01-11

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

MRKH syndrome

Interventions

96 patients with MRKH will be included. The controlgroup exists of 96 healthy women, already sampled. No interventions. Blood samples will be analyzed for Y-chromosome-specific real-time quantitative

Eligibility

Inclusion criteria

Inclusion criteria: - Diagnosed with MRKH syndrome - Age ≥ 18 years

Exclusion criteria

Exclusion criteria: none

Design outcomes

Primary

Measure	Time frame
The primary outcome is the difference in occurrence of microchimerism (with an extra male cell line) in MRKH patients vs. controls.	—

Secondary

Measure	Time frame
The secondary outcome is the presence of chimerism in non-hematopoietic tissue (buccal cells) in MRKH patients.	—

Contacts

Public ContactHenrike Peters

VUmc, afdeling reproductive medicine. PK 5x -194.

h.peters@vumc.nl0204440561

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)