Respiratory bacteria and viruses in the nasopharynx of infants and parents.

Cross-sectional surveillance study on pneumococcal serotypes and other pathogens in nasopharyngeal samples from infants and parents performed 6.5 years after introduction of pneumococcal vaccination in The Netherlands.

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON28043

Enrollment

990

Registered

2012-09-18

Start date

2012-10-01

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Asymptomatic pneumococcal carriage, infectious diseases, Streptococcus pneumoniae, viral presence, bacterial commensals

Interventions

None listed

Eligibility

Inclusion criteria

Inclusion criteria: 1. Healthy infants; 2. Parents are willing and able to participate; 3. Infant is 11 or 24 months old (± 4 weeks) dependent on the group; 4. Infant received 3 pneumococcal vaccinations before the age of 6 months (11-month-old infant) and the 11 month booster (24-month-old infant); 5. Informed consent signed by both parents/legal representatives.

Exclusion criteria

Exclusion criteria: Infants: 1. Previous vaccinations not according to Dutch 3+1 schedule; 2. Previous vaccinations with other pneumoccocal vaccines than Synflorix (11-month-old infant) or Prevenar-7 (24-month-old infant). Infants and parents of 24-month-old infants: 1. Chromosomal abnormalities or craniofacial abnormalities (like Trisomy 21 or schisis), known or suspected immunodeficiency disease or other medical conditions that will severely affect immunological responses to vaccinations or nasopharyngeal carriage rates; 2. Coagulation disorder/anticoagulant medication.

Design outcomes

Primary

Measure	Time frame
The percentage of total vaccine- and non-vaccine pneumococcal serotypes found in the nasopharyngeal swabs from infants at 11 and 24 months of age by conventional culture. Serotyping is performed at single colony level by Quellung reaction as in previous surveillance studies.	—

Secondary

Measure	Time frame
1. The percentage of total vaccine- and non-vaccine pneumococcal serotypes found in the nasopharyngeal swabs from parents of the 24-month-old infants as determined by culture and Quellung; 2. The percentage of infants and parents with nasopharyngeal swabs positive for S. aureus, H. influenzae and M. catarrhalis as determined by culture; 3. The percentage of individual pneumococcal serotypes found in the nasopharyngeal swabs from infants at 11 and 24 months of age and parents of the 24-month-old infants as determined by culture and Quellung.	—

Measure

Time frame

1. The percentage of total vaccine- and non-vaccine pneumococcal serotypes found in the nasopharyngeal swabs from parents of the 24-month-old infants as determined by culture and Quellung; 2. The percentage of infants and parents with nasopharyngeal swabs positive for S. aureus, H. influenzae and M. catarrhalis as determined by culture; 3. The percentage of individual pneumococcal serotypes found in the nasopharyngeal swabs from infants at 11 and 24 months of age and parents of the 24-month-old infants as determined by culture and Quellung.

—

Contacts

Public ContactAlienke Wijmenga-Monsuur

RIVM

alienke.wijmenga@rivm.nl

Outcome results