Primary prostate cancer
Conditions
Interventions
Intravenous 68Ga-PSMA injection and ex vivo CLI imaging of excised prostate specimen.
Sponsors
This research is supported by KWF Kankerbestrijding and Technology Foundation STW, as part of their joint strategic research programme ‘Technology for Oncology’ (Grant number 15175).
Eligibility
Inclusion criteria
Inclusion criteria: - Primary prostate cancer >18 year - Eligible for PSMA PET scan (PSA=20 ng/mL or =cT3 or Gleason =7) - Tumour larger than 1.5cm on MRI. - Signed informed consent - Voluntary understanding - Scheduled for radical prostatectomy surgery - PSMA uptake on pre-operative 68Ga-PSMA PET scan
Exclusion criteria
Exclusion criteria: - Usage of Indocyanine green (ICG) during surgery - No PSMA uptake on clinical PET/CT-scan - Subjects who have an existing medical condition that would compromise their participation in the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The objective of this study is to assess the feasibility of 68Ga-PSMA CLI for intra-operative analysis of prostate surgical specimens. | — |
Secondary
| Measure | Time frame |
|---|---|
| Radiation dosimetry to the OR personnel during the radical prostatectomy . | — |
Contacts
Public ContactJudith olde Heuvel
Netherlands Cancer Institute - Antoni van Leeuwenhoek
Outcome results
None listed