Preterm infants Insulin-like growth factor I Growth Body composition
Conditions
Interventions
Preterm infants (born < 32 weeks) fed limited energy- and nutrient-enriched preterm follow-up formula at a postmenstrual age of 32-33 weeks will be compared to preterm infants fed according to the sta
Sponsors
VU University medical center
Eligibility
Inclusion criteria
Inclusion criteria: In October 2016 the following changes were made: - An additional reference group (n=100) of infants born between 32 and 42 weeks of gestation has been added for the analysis of endocrine parameters in cord blood; In January 2017 the following changes were made: - The intervention is stopped, because of insufficient number of formula-fed infants; - The number of participants with a gestational age less than 32 weeks was reduced from 150 to 70. Inclusion criteria: 1. Written and informed consent from either the parents or the legal guardians who at least have professional working proficiency of the Dutch, English or French language. 2. Gestational age of 24 to 32 weeks. 3. Arterial catheter in situ. In order to be eligible for cord blood analysis, a subject must meet all of the following criteria: 1. Gestational age of 24 to 42 weeks 2. Written and informed consent from either the parents or the legal guardians who at least have professional working proficiency of the Dutch, English or French language.
Exclusion criteria
Exclusion criteria: A substantial congenital anomaly based on a chromosomal or syndromal disorder with a known effect on growth and body composition.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Growth (height, weight, body proportions and growth pattern) 2. Body composition 3. Growth-related endocrine parameters | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Psychomotor development 2. Bone mineralization 3. Lipid status 4. Blood pressure | — |
Contacts
Public ContactDFJ Yumani
VU University Medical Center
Outcome results
None listed