Effect of vitamin K supplementation on bone mineral density and bone turnover, and on markers of soft tissue calcification in Greek postmenopausal women.

Effect of vitamin K supplementation on bone mineral density of the spine and hip, on markers of osteoblast and osteoclast activity, and on markers of soft tissue calcification, in Greek postmenopausal women.

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON27983

Enrollment

140

Registered

2008-08-06

Start date

2008-09-01

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postmenopausal women, bone loss, bone turnover, vitamin K, menaquinones, bone mineral density, Greek

Interventions

- No intervention - Dairy product low vitamin K - Dairy product + 100 mcg vitamin K1 - Dairy product + 100 mcg vitamin K2 Number of participants per intervention group: There will be two intervent

Eligibility

Inclusion criteria

Inclusion criteria: 1. Apparently healty Greek 2. Postmenopausal women 3. Age 55-70 years 4. Postmenopausal for >5 years 5. T-score lumbar spine based on DXA >-2.5 6. Habitual calcium intake =<800 mg/day 7. Cigarettes <5 per day 8. BMI perferable <30 9. Willing to complete a 12 month study and product (milk) consumption

Exclusion criteria

Exclusion criteria: 1. Postmenopausal for 800 mg/day 8. Cigarettes >5/day 9. BMI >33 10. Lactose intolerant 11. Cow's milk protein allergy

Design outcomes

Primary

Measure	Time frame
- Bone mineral density of hip and spine - Effect on parameters of bone turnover in blood and urine	—

Secondary

Measure	Time frame
- Carboxylation of MGP - Anthropometry	—

Contacts

Public ContactA. Schaafsma

anne.schaafsma@frieslandfoods.com+31 (0)6 53241313

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)