Brain activation during sentence processing in Parkinson's disease: an event related fMRI-study.

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON27976

Enrollment

Registered

2006-09-26

Start date

2006-12-01

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

To test our hypothesis we developed six conditions by crossing two within subject factors in a 2x2x3 factorial design. The first factor is word order with two levels: active and passive. The second factor is grammaticality with three levels: no violation, an inflectional morphology violation, and a transitivity violation condition. On the basis of these six conditions we created a set of materials that will be used in two different experiments. We will first conduct an event related fMRI-experim

Interventions

No interventions. It is observational research with the use of FMRI (no use of invasive techniques).

Eligibility

Inclusion criteria

Inclusion criteria: 1. Idiopathic Parkinson's Disease (PD) 2. Hoehn and Yahr Stage 1 to Stage 3 3. Normal vision and hearing 4. Able to give informed consent 5. Older than 40 years 6. Dutch as first language 7. Right-handed 8. Normal structural MRI scan

Exclusion criteria

Exclusion criteria: 1. Not optimally medicated 2. Neurostimulator 3. Implanted pump (e.g. apomorphine) 4. Dementia (MMSE-score 18) 6. Another neurological disease 7. Another akinetic-rigid disorder 8. Another movement disorder 9. No normal structural MRI scan

Design outcomes

Primary

Measure	Time frame
For the fMRI analysis data, a main effect of group is expected. The level of activation in the BG will be reduced in the PD patient group compared to the healthy control group. For the within subject factors we expect to find a main effect of grammaticality. In the healthy elderly subject group, we expect that the processing of the grammatical incorrect sentences will activate the BG more compared to the processing of the grammatical correct sentences. For the behaviourally data, we expect to find slower reaction times (RTs) for the processing of non-canonical ungrammatical sentences (i.e. passive sentences with a violation) in both subject groups. However the RTs will be significantly more affected in the PD group compared to the healthy elderly subject group.	—

Measure

Time frame

For the fMRI analysis data, a main effect of group is expected. The level of activation in the BG will be reduced in the PD patient group compared to the healthy control group. For the within subject factors we expect to find a main effect of grammaticality. In the healthy elderly subject group, we expect that the processing of the grammatical incorrect sentences will activate the BG more compared to the processing of the grammatical correct sentences. For the behaviourally data, we expect to find slower reaction times (RTs) for the processing of non-canonical ungrammatical sentences (i.e. passive sentences with a violation) in both subject groups. However the RTs will be significantly more affected in the PD group compared to the healthy elderly subject group.

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Contacts

Public ContactK. Colman

Oude Kijk in’t Jatstraat 26

k.s.f.colman@rug.nl+31(0)50 363 81 35

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)