Herpetic keratitis
Conditions
Interventions
The diagnostic method used in this study to adjust medication will depend on the study-arm. Diagnostic outcome (active versus inactive HSK) will determine whether treatment is (re)started or stepped u
Sponsors
Het Oogziekenhuis Rotterdam (OZR)
Postbus 70030
3000-LM Rotterdam
Eligibility
Inclusion criteria
Inclusion criteria: 1. Age ¡Ý 18 years; 2. Informed consent; 3. Unilateral disease; 4. Immune stromal keratitis in herpetic infection involving the optical axis; 5. Capable to cooperate (sitting still, fixing test light); 6. Group 1 and 2: At least 6 months after a clinical overt recurrence; 7. Group 3 and 4: At presentation with recurrence.
Exclusion criteria
Exclusion criteria: 1. Patients with proven ACV resistant strains; 2. Severe necrotizing herpetic keratitis; 3. Severe herpes related macula in the optical axis preventing visualisation of endothelium; 4. Herpetic stromal infection exclusively located in the peripheral 2 mm of the cornea; 5. Pre-existing ocular disease requiring surgical intervention within 12 months; 6. Pre-existing uncontrolled steroid glaucoma.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| BCVA at 12 and 24 months follow up. Number of recurrences recognized in an earlier state by IVCM compared to slit lamp examination. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Side effects of treatment; 2. Amount of steroids used during 24 months follow up; 3. Dose of antiviral treatment used during 24 months follow up. | — |
Contacts
Public ContactL. Remeijer
PO Box 70030
Outcome results
None listed