Health-related quality of life Social participation Cognitive functioning Hearing impairment Behavioural disfunctioning Medical care consumption Economic self-sufficiency
Conditions
Interventions
The participants are invited cross-sectionally and to complete the following online internet-based questionnaires:
- PROMIS Global Health 10
- PROMIS-29 Profile
- PROMIS Satisfaction 2.0
- Weis
Sponsors
VU Medical Center
Eligibility
Inclusion criteria
Inclusion criteria: Children were included at baseline when the causing pathogen of bacterial meningitis was Neisseria meningitides, Streptococcus pneumoniae, Streptococcus agalactiae, Escherichia coli or Listeria monocytogenes. Currently, the mean age of the first cohort will be 26 years (± 2.3 SD, range 22.0-31.0) and the mean age of the second cohort will be 19,7 years (± 1,89 SD, range 16.0-24.0)
Exclusion criteria
Exclusion criteria: Children in the original cohorts were excluded when they were infected by Hib or other less common pathogens. Furthermore, children with ‘complex onset’ of meningitis (defined as: meningitis secondary to immunodeficiency states, central nervous system surgery, cranial trauma or cerebrospinal fluid shunt infections or relapsing meningitis) were excluded. Moreover, because the intention was to study the more subtle neuropsychological sequelae, children having cognitive or behavioural problems prior to meningitis, children or adolescents in whom severe cognitive disabilities (a ‘specialist’s diagnosis’ of mental retardation or pervasive developmental disorder) were diagnosed before or after meningitis were excluded and will be excluded in the present study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Health-related quality of life (considered aberrant if PROMIS Global Health 10 and PROMIS-29 Profile scored < 50) | — |
Secondary
| Measure | Time frame |
|---|---|
| - Subjective hearing (divided in groups with severe hearing disability, moderate hearing disability and very little hearing disability) - Executive functioning (clinically aberrant score >60) - Behavioural and adaptive functioning (scores of ASR will be compared to norms, descriptive statistics will be performed on the Weiss functional impairment rating scale self-report) - Economic self-sufficiency (based on scores of the iMTA productivity questionnaire) - Medical care consumption (based on scores of the iMTA Medical Consumption Questionnaire) - Academic achievement | — |
Contacts
Public ContactO. El Tahir
Outcome results
None listed