Subfertility affects approximately one in ten couples planning conception. Among subfertile women, about 30% are overweight or even obese. Epidemiological data suggest that the reduction of overweight will increase the chances of conception, decrease pregnancy complications and improve perinatal outcome. In small intervention studies beneficial reproductive effects of improvement of lifestyle leading to a reduction in body weight have been demonstrated. The British Fertility Society advises that
Conditions
Interventions
The intervention consists of a structured lifestyle program of six months, which aims a realistic weight loss of at least 5% to10%, achieved by the combination of a healthy diet (caloric reduction of
the Groninger Overweight And Lifestyle study (GOAL)). Following six months of lifestyle intervention patients will start fertility treatment as indicated in the “usual care” group.In the “usual care”
Sponsors
ZonMW
Laan van Nieuw Oost Indië 334
2593 CE Den Haag
T: 07-3495111
Eligibility
Inclusion criteria
Inclusion criteria: 1. Subfertile women (age 18-38) with a BMI between 29 and 40
Exclusion criteria
Exclusion criteria: 1. Are azoospermia 2. Severe endometriosis 3. Chronic anovulation due to WHO III 4. Endocrinopathies.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| - Primary endpoint is the birth of a healthy singleton after vaginal delivery of at least 37 weeks gestation. | — |
Secondary
| Measure | Time frame |
|---|---|
| - Secondary outcome parameters are: - number of fertility treatments (OI, IUI, IVF, ICSI) - clinical and ongoing pregnancy rates - perinatal outcome - complications - quality of life - body weight - waist circumference - behaviour influencing weight, i.e. - nutritional habits - exercise pattern - smoking habits - blood pressure - glucose/insulin ratio (HOMA) - costs. | — |
Contacts
Public ContactA. Hoek
University Medical Center Groningen (UMCG) Section of Reproductive Medicine Dept. Obstetrics and Gynaecology
Outcome results
None listed