Central sleep apnea - sleep disorder
Conditions
Interventions
The intervention is the regulation of nocturnal PETCO2 during one night by means of a new setup based on literature. The dynamic rebreathing setup consists of a sealed CPAP masker, capnograph, tubes a
Sponsors
Medisch Spectrum Twente
Eligibility
Inclusion criteria
Inclusion criteria: - = 18 years of age - Hypocapnic CSAS (i.e. AHI =15, = 50% central events, CAI = 5, presence of >15% Cheyne Stokes Respiration) - Written informed consent (IC) from the subject prior to participation - CPAP nasal mask use = 4 hours/night for = 5 days a week.
Exclusion criteria
Exclusion criteria: - Unable to understand and read the Dutch language - Hypercapnia during daytime (PaCO2 = 6 kPa) and/or metabolic compensation (bicarbonate > 27 mmol/l) - Hypercapnia during the reference PSG (mean PETCO2 = 6.3 kPa during N2 sleep excluded from CSR and apnea) - History of neuro(muscular) disease and/or kyphoscoliosis - NYHA Functional Classification class IV - Chronic obstructive pulmonary disease stage 3 / 4 (GOLD-criteria) - Drug abuse - Use of drug with known influence on respiratory drive that cannot be stopped one week prior to the PSGs (e.g. analeptics and opioids) - Patients breathing through the mouth during night (based on own experience or partner’s experience) - Patients breathing through the mouth during sleep (according to CPAP read-out or their own / partner’s experience) - Pregnant women
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study parameters are the ability to regulate PETCO2, quantified by the percentage of time spent in predetermined patient specific PETCO2 range, and the user experiences, quantified by a numeric rating scale based questionnaire. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary study parameters are the differences between the control night and intervention night of the following parameters: Apnea/hypopnea index (AHI) Central apnea/hypopnea index (CAHI) Central apnea index (CAI) Central hypopnea index (CHI) Arousal index (AroI) Mean ventilation (L/min) Percentage of total sleep time (TST) with oxygen desaturation (SpO2<90%) Total duration of CSR divided by TST Percentages of TST spent in each sleep stage (N1, N2, N3 and REM) Loop gain, defined as the hyperpnea length/cycle length of CSR. | — |
Contacts
Public ContactGerike Buitenhuis
Medische Spectrum Twente
Outcome results
None listed