The effect of collagen supplementation on collagen metabolism after total hip arthroplasty.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON27884

Enrollment

Registered

2021-07-20

Start date

2021-09-01

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Osteoarthritis of the hip

Interventions

The intervention consists of two-weeks of (15g) daily collagen supplementation or isoenergetic placebo (maltodextrine) following total hip arthroplasty.

Eligibility

Inclusion criteria

Inclusion criteria: • Written informed consent • With osteoarthritis and due for total hip arthroplasty • = 60 years old • BMI 18.5-35 kg/m2

Exclusion criteria

Exclusion criteria: • Taking medications known to influence protein metabolism • Collagen allergy • Diabetes mellitus • Alcohol abuse • Surgical intervention in past four weeks • GFR <20mL/min/1.73m2 • Rheumatoid arthritis • Collagen disorders • Cancer • Gastrointestinal disease

Design outcomes

Primary

Measure	Time frame
The main endpoints of this study are the changes in serum concentrations of biomarkers of collagen metabolism perioperatively and up to two weeks after surgery. These biomarkers represent bone and cartilage synthesis (N-terminal propeptide of type I and type II collagen, respectively: P1NP, P2NP) and breakdown (C-terminal telopeptide of type I and type II collagen, respectively: CTx1, CTx2).	—

Secondary

Measure	Time frame
Secondary endpoints include changes in plasma amino acid concentrations and pain and functional outcomes.	—

Contacts

Public ContactAlejandra Monsegue

Maastricht University

a.monsegue@maastrichtuniversity.nl+31433881509

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)