Pilotstudy: Probiotics in children with atopic dermatitis and food allergy: is there an in vivo or in vitro effect on the immunological response?

Probiotics in children with atopic dermatitis and food allergy: is there an in vivo or in vitro effect on the immunological response?

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON27882

Enrollment

Registered

2005-08-23

Start date

2003-03-01

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Atopic dermatitis and food allergy.

Interventions

Active group: 3 months treatment with a daily dose of a mixture of probiotics. Placebo group: 3 months treatment with a daily dose of placebo.

Eligibility

Inclusion criteria

Inclusion criteria: 1. 0-3 years of age; 2. Atopic dermatitis; 3. History strongly suggestive of food allergy or positive placebo-controlled food challenge; 4. IgE RAST >= 0.7 kU/l for at least 2 food allergens; 5. SPT >= 2+ for at least 2 food allergens.

Exclusion criteria

Exclusion criteria: 1. Other systemic diseases; 2. Immunocompromized; 3. Systemic treatment with immunomodulating drugs.

Design outcomes

Primary

Measure	Time frame
Allergen-specific T cell response, B cell response.	—

Secondary

Measure	Time frame
SCORAD, IgE RAST, SPT.	—

Contacts

Public ContactE. Hoffen, van

University Medical Center Utrecht (UMCU), Department of Dermatology/Allergology (G02.124), P.O. Box 85.500

+31 (0)30 2507389

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)