Cognitive functioning
Conditions
Interventions
Cannabis users will receive 300 µg/kg THC and placebo. Cannabis and placebo will be administered using a Volcano vaporizer, which will also ensure blinding.
Alcohol users will receive alcohol and pla
Sponsors
Maastricht University
Eligibility
Inclusion criteria
Inclusion criteria: For alcohol users: 1. As using on average 21 to 50 alcoholic drinks/week for males or 15 to 35 alcoholic drinks/week for females during the last year, drinking alcohol both during the week as during the weekend; 2. Not currently using cannabis, experimental use of cannabis is allowed if it is more than a year ago. Cannabis users: 1. Used between 3 and 10 times a week during the previous year; 2. Uses between 1 and 14 units of alcohol/week. Control group: 1. Not currently using cannabis, experimental use of cannabis is allowed if it is more than a year ago; 2. Incidental use of alcohol (between 1 and 14 units of alcohol/week). All groups: 1. Age between 18 and 40 years; 2. Free from psychotropic medication; 3. Good physical health as determined by medical examination and laboratory analysis; 4. Absence of any major medical, endocrine and neurological condition; 5. Normal weight, body mass index (weight/height2) between 18.5 and 28 kg/m2; 6. Written Informed Consent.
Exclusion criteria
Exclusion criteria: 1. History of drug abuse (other than the use of cannabis for the cannabis group and alcohol for the alcohol group) or addiction (determined by the medical questionnaire, drug questionnaire and medical examination); 2. Pregnancy or lactation; 3. Hypertension (diastolic> 90; systolic> 140); 4. Current or history of psychiatric disorder (determined by the medical questionnaire and medical examination); 5. Liver dysfunctioning; 6. (Serious) side effects to previous cannabis or alcohol use; 7. History of cardiac dysfunctions (arrhythmia, ischemic heart disease,…); 8. For women: No use of a reliable contraceptive.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Implicit associations of cannabis and alcohol users. | — |
Secondary
| Measure | Time frame |
|---|---|
| Activation of the reward neurocircuitry in the brain and aggressive behavior. | — |
Contacts
Public ContactE.L. Theunissen
Outcome results
None listed