Intestinal failure
Conditions
Interventions
None listed
Sponsors
Erasmus Medical Center - Sophia Children's Hospital
Eligibility
Inclusion criteria
Inclusion criteria: Children, newly diagnosed with intestinal failure in the Erasmus MC-Sophia Children's Hospital. Three groups of children will be included: 1. Children with congenital gastro-intestinal anomalies with involvement of the small intestine, independent of expected use of parenteral nutrition. 2. Neonates with an expected use of parenteral nutrition ≥ 1 week after a gastrointestinal intervention (laparotomy). 3. Children with a (suspected) motility disorder or intrinsic disorder of the intestinal mucosa with an expected use of parenteral nutrition > 2 weeks and children with an expected use of parenteral nutrition ≥ 1 week after a gastrointestinal intervention (laparotomy) after the neonatal period. Furthermore, children already known with intestinal failure who receive parenteral nutrition at home and visit the intestinal failure outpatient clinic will be included, both in the Erasmus MC - Sophia Children's Hospital and the AMC - Emma Children's Hospital.
Exclusion criteria
Exclusion criteria: Participating in an intervention study, interfering with primary outcome of this study. Absence of written informed consent Insufficient knowledge of the Dutch language
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Body composition measured, defined by %BF Parenteral nutrition (time-weighted area under the curve for % of total kilocalories provided by parenteral nutrition and duration of PN) | — |
Secondary
| Measure | Time frame |
|---|---|
| Growth, defined by weight, length, head circumference and calculated SD scores. Mid-upper arm circumference scores. Bone health, defined by bone mineral density (g/cm2), bone mineral content (g) and bone mineral apparent density (g/cm3), bone age and bone health index. | — |
Contacts
Public ContactJM Hulst
Erasmus MC - Sophia Children's Hospital
Outcome results
None listed