Rhegmatogenous retinal detachment (RRD) is a sight-threatening condition, most often initiated by a posterior vitreous detachment-associated retinal tear. A recent study found an incidence of RRD in the Netherlands of 18.2 per 100,000 people.
Conditions
Interventions
None
Sponsors
University Medical Center Groningen
Eligibility
Inclusion criteria
Inclusion criteria: 1. Willingness to participate. 2. Patients, newly diagnosed with retinal detachment, scheduled for vitrectomy. 3. Age: >18 years.
Exclusion criteria
Exclusion criteria: 1. Dark coloured skin that impairs the reliability of the autofluorescence measurement. 2. Skin abnormalities on both arms that will impair the reliability of the autofluorescence measurement. 3. Local or general active infection or inflammatory disease. 4. Known renal disease with impairment of renal function class CKD ≥3 (≤ 60 ml/min according to eGFR), current dialysis treatment, or a history of renal transplantation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Surgical failure | — |
Secondary
| Measure | Time frame |
|---|---|
| 2. Skin autofluorescence 3. Vitreous body AGE levels 4. Vitreous body sRAGE levels 5. plasma sRAGE levels 6. Glyoxalase polymorphisms 7. RAGE polymorphisms 8. Age, 9. gender, 10. surface area of retinal detachment, 11. number of retinal defects, 12. macular detachment, 13. detachment duration, 14. pre-operative PVR grade, 15. presence of diabetes, 16. pseudophakia, 17. intraoperative use of gas or silicon oil, 18. intraoperative cryotherapy, intraoperative minor hemorrhage. | — |
Contacts
Public ContactL.I. Los
University Medical Center Groningen (UMCG), Department of Ophthalmology P.O. Box 30.001
Outcome results
None listed