Exhaled breath analysis to diagnose acute lung injury.

Bedside exhaled breath octane measurements for the diagnosis and monitoring of acute respiratory distress syndrome in intubated and mechanically ventilated patients.

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON27817

Enrollment

500

Registered

2018-07-19

Start date

2019-01-01

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

ARDS, non-invasive diagnostic tests, early detection, octane Dutch: ARDS, niet-invasieve diagnostische methoden, vroege detectie, octane

Interventions

None listed

Eligibility

Inclusion criteria

Inclusion criteria: Intubated and mechanically ventilated for less than 48 hours.

Exclusion criteria

Exclusion criteria: • Patient is expected to be deceased within 24 hours. • Exhaled breath collection deemed inappropriate by the attending physicians. • Active withdrawal from the study by the patient or his/her legal representative. • Present admission to the ICU is a readmission.

Design outcomes

Primary

Measure	Time frame
Exhaled breath concentration of octane, measure by compact gas-chromatography.	—

Secondary

Measure	Time frame
• Volatile organic compounds in exhaled breath measured by gas-chromatography and mass-spectrometry. • Protein patterns in fluid from the heat-moist exchanger. • Non-invasive imaging techniques: o Lung ultrasound o Electrical impedance tomography. • Lung injury prediction score. • ARDS as defined by the Berlin Definition • Therapeutic response in ARDS patients • ARDS phenotypes defined by clinical characteristics and by a biomarker profile of plasma biomarkers	—

Measure

Time frame

• Volatile organic compounds in exhaled breath measured by gas-chromatography and mass-spectrometry. • Protein patterns in fluid from the heat-moist exchanger. • Non-invasive imaging techniques: o Lung ultrasound o Electrical impedance tomography. • Lung injury prediction score. • ARDS as defined by the Berlin Definition • Therapeutic response in ARDS patients • ARDS phenotypes defined by clinical characteristics and by a biomarker profile of plasma biomarkers

—

Contacts

Public ContactLieuwe D.J. Bos

Academic Medical Center, Room G3-228 Meibergdreef 9

l.d.bos@amc.uva.nl+31 (0)20 5666345

Outcome results