GnRH agonist downregulated IVF/ICSI cycles
Conditions
Interventions
hCG administration for follicular maturation when the dominant follicle measures 18 mm compared to hCG administration for follicular maturation when the dominant follicle measures 22 mm
Sponsors
Academic Medical Center
Eligibility
Inclusion criteria
Inclusion criteria: 1. Age between 18 and 42 and 11 months; 2. Valid indication for IVF or ICSI; 3. Undergoing their first or second IVF/ICSI attempt; 4. Normal FSH levels ( 5 for women between 40 and 43.
Exclusion criteria
Exclusion criteria: 1. Endocrinopathological disease as: PCOS, cushing syndrome, adrenal hyperplasia, hyperprolactinaemia, acromegaly, hypothalamic amenorrhea, hypothyroidy, diabetes mellitus type I; 2. Premature ovarian failure defined as a FSH level on cycle-day 3 of ¡Ý 15 IU at the age of 40; 3. Low responders defined as follicle growth of less than 3 follicles during controlled ovarian hyperstimulation (including the dominant follicle).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Ongoing pregnancy rate, defined as a positive foetal heartbeat by ultrasound at 10 weeks after oocyte retrieval. | — |
Secondary
| Measure | Time frame |
|---|---|
| Endometrium thickness, 3-layer aspect Total days of controlled hyper stimulation Total amount of rFSH used Total number of retrieved oocytes Number of Score I oocytes (IVF only) Number of metaphase II oocytes (ICSI only) Fertilization rate Number and quality of embryos Pronuclear morphology Presence of early cleavage Daily morphological quality of embryos until transfer Number of embryos suited for cryo-preservation OHSS/ discontinuation due a high risk of OHSS Biochemical and clinical pregnancy rates, defined as a increase in serum HCG or a positive pregnancy test and positive heartbeat by ultrasound at 7 weeks after oocyte retrieval, respectively. | — |
Contacts
Public ContactM.H. Mochtar
Academical Medical Center, Center for Reproductive Medicine
Outcome results
None listed