Chronic Kidney Disease (chronische nierinsufficiëntie)
Conditions
Interventions
Low phosphate diet combined with phosphate supplement or placebo
Sponsors
University Medical Center Groningen
Eligibility
Inclusion criteria
Inclusion criteria: • CKD • Estimated GFR >30 mL /min/1.73 m2 • Residual albuminuria ≥ 500 mg /day despite treatment with optimally dosed ACEi or ARB. • Age ≥ 18 years
Exclusion criteria
Exclusion criteria: • Current use of phosphate binder therapy • Hyperphosphatemia >2.00 mmol/L • Hypocalcaemia (corrected serum calcium 2.60 mmol/L) • Hyperkalemia (serum potassium >5.50 mmol/L) • Blood pressure >180/100 mmHg after study run-in period. • Chronic diarrhea (>5 diarrhea stools/day for >2 weeks • Chronic inflammatory bowel disease • Chronic NSAID use • Diabetes Mellitus • Non-glomerular source of proteinuria • Contraindications to ACEi therapy or high/low phosphate intake • Unstable disease (at the discretion of the nephrologist, such as persistent renal function loss > 6 mL/min/1.73m2 per year, not explainable by intercurrent events, with accompanying changes in serum creatinine and urea).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Residual albuminuria (24h urine collection) | — |
Secondary
| Measure | Time frame |
|---|---|
| C-terminal FGF23 levels, 24-hourly phosphorus excretion, serum phosphate levels, serum calcium levels, 24-hourly calcium excretion, residual proteinuria, systolic blood pressure, Serum calcification propensity | — |
Contacts
Public ContactM.A. de Jong
Universitair Medisch Centrum Groningen - Afdeling Nefrologie, HPC AA53
Outcome results
None listed