Gene expression during ciliagenesis: Towards a novel candidate gene list for Primary Ciliary Dyskinesia.

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON27807

Enrollment

Registered

2013-03-04

Start date

2013-05-01

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Primary Ciliary Dyskinesia

Interventions

Nasal curette and brush biopsies will be performed on healthy volunteers to obtain respiratory epithelial cells. Cells will be cultured and RNA will be isolated at three different time points during c

Eligibility

Inclusion criteria

Inclusion criteria: ≥ 18 years of age.

Exclusion criteria

Exclusion criteria: 1. Any signs of upper or lower airway infection; 2. Coagulation disorders (or any symptoms of easy bruising, heavy bleedings); 3. Use of anti-coagulants.

Design outcomes

Primary

Measure	Time frame
Gene expression levels and pattern.	—

Secondary

Measure	Time frame
Cell culture success rate with brush biopsies.	—

Contacts

Public ContactT. Paff

Postbus 7057

t.paff@vumc.nl+31 (0)20 4445491

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)