Nutrition and asthma: subgroups and outcomes

Observational study into the Relationship between Asthma and Nutrition in asthma sub-Groups including clinical, functional and inflammatory Endpoints

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON27753

Enrollment

150

Registered

2019-03-18

Start date

2019-05-01

Completion date

Unknown

Last updated

2024-06-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

(Severe) asthma

Interventions

None listed

Eligibility

Inclusion criteria

Inclusion criteria: - Asthma diagnosis according to GINA guidelines - Step 3-5 treatment (GINA guidelines) - Aged =18 year - Proficient in speaking and understanding Dutch

Exclusion criteria

Exclusion criteria: - Pregnancy - Concurrent respiratory disease (e.g. pneumonia, bronchitis, COPD) - Pulmonary infection or asthma exacerbation in the past 4 weeks

Design outcomes

Primary

Measure	Time frame
Nutritional intake and status: - Intake: dietary intake of macro- and micronutrients and food groups, and the Dietary Inflammatory Index; - Status: body composition (fat mass and fat-free mass), anthropometry (BMI, waist- and hip circumference), muscle mass (urinary creatinine excretion), muscle strength (handgrip strength), functional exercise capacity (6-minute walking test), and nutrient status (plasma vitamins, minerals, lipids).	—

Measure

Time frame

Nutritional intake and status: - Intake: dietary intake of macro- and micronutrients and food groups, and the Dietary Inflammatory Index; - Status: body composition (fat mass and fat-free mass), anthropometry (BMI, waist- and hip circumference), muscle mass (urinary creatinine excretion), muscle strength (handgrip strength), functional exercise capacity (6-minute walking test), and nutrient status (plasma vitamins, minerals, lipids).

—

Secondary

Measure	Time frame
Clinical, functional and inflammatory characteristics of asthma: - Clinical: asthma control (ACQ), quality of life (AQLQ), hospital admissions, exacerbation frequency, and use of oral corticosteroids (health care utilization) - Functional: pulmonary function (spirometry), and medication use; - Inflammatory: airway inflammation (FeNO, sputum mRNA, leukocytes and cell differential), systemic inflammation (plasma albumin, IL-6, TNF-a, CRP), innate immune activity (plasma leukocytes and cell differential), and atopic status (IgE and RAST)	—

Measure

Time frame

Clinical, functional and inflammatory characteristics of asthma: - Clinical: asthma control (ACQ), quality of life (AQLQ), hospital admissions, exacerbation frequency, and use of oral corticosteroids (health care utilization) - Functional: pulmonary function (spirometry), and medication use; - Inflammatory: airway inflammation (FeNO, sputum mRNA, leukocytes and cell differential), systemic inflammation (plasma albumin, IL-6, TNF-a, CRP), innate immune activity (plasma leukocytes and cell differential), and atopic status (IgE and RAST)

—

Contacts

Public ContactEdith Visser

University of Groningen / Medical Centre Leeuwarden

h.j.visser@rug.nl0582867680

Outcome results