Does cerebral hyperglycaemia lead to activation of the neurotoxic polyol pathway?

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON27740

Enrollment

Registered

2021-03-23

Start date

2021-03-23

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

cerebral glucose metabolism

Interventions

None.

Eligibility

Inclusion criteria

Inclusion criteria: • Spinal anaesthesia for elective surgery • 18 years and older

Exclusion criteria

Exclusion criteria: • Neurometabolic disorder

Design outcomes

Primary

Measure	Time frame
The association between cerebral glucose concentration and cerebral sorbitol and fructose concentration.	—

Secondary

Measure	Time frame
? The correlation between plasma glucose levels with CSF glucose levels ? The correlation between cognitive function and cerebral glucose, sorbitol and fructose ? Differences in the above mentioned objectives between patients with low plasma glucose, high plasma glucose and DM-patients	—

Contacts

Public ContactMark van Zuylen

Amsterdam UMC - Location AMC

m.l.zuylenvan@amsterdamumc.nl+31629600111

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)