nosocomial infections Intensive Care antimicrobial prophylaxis probiotic prophylaxis cross-over clinical trial
Conditions
Interventions
Participating patients in the SDD units will be treated with 0.5 gram of an oral paste containing 2% polymyxin E, 2% gentamicin and 2% amphotericin B four times daily applied to the buccal cavity as w
Sponsors
Maastricht University Medical Centre (MUMC)
Eligibility
Inclusion criteria
Inclusion criteria: All consecutive patients admitted to the ICU who are older than 18 years and have an expected duration of mechanical ventilation of at least 48 hours, expected length of stay at the ICU of at least 72 hours or both.
Exclusion criteria
Exclusion criteria: previous admission to the ICU within 3 months, known hypersensitivity to the study medication, pregnancy, contra-indication for enteral feeding, perceived imminent death, and participation in another investigational study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of all infections occurring > 48 hours after admission at the ICU during the intervention and follow up period. | — |
Secondary
| Measure | Time frame |
|---|---|
| - ICU and in-hospital mortality rate; - prevalence of antibiotic resistant microorganisms - additional and total antibiotic use. | — |
Contacts
Public ContactA. Verbon
Maastricht University Medical Centre Department of Medical Microbiology PO Box 5800
Outcome results
None listed