Acute Coronary Syndrome (Unstable Angina, Non ST-Elevatiom Myocardial infarction and ST-elevation Myocardial Infarction)
Conditions
Interventions
None, strictly observational post-ACS study.
Sponsors
Principal investigator: Prof. Eric Boersma, PhD, MSc, FESC. Department of Cardiology, unit Clinical Epidemiology, ErasmusMC Rotterdam, The Netherlands
Eligibility
Inclusion criteria
Inclusion criteria: 1. Complaints of typical ischemic chest pain, lasting 10 minutes or more within the preceding 24 hours prior to presentation; 2a. ECG: (Non-)persistent ST segment elevation > 1.0 mm in two or more contiguous leads or dynamic ST segment depression > 1.0 mm in two or more contiguous leads; OR 2b. CK-MB or Troponin I > the upper normal limit or Troponin T > 0.05 µg/L (ng/ml); 3. Age ≥ 40 years; 4. Presence of ≥ 2 conventional risk factors (Age ≥ 65 years in males, age ≥ 70 years in females, diabetes mellitus, hypertension, hypercholesterolemia, current smoking, prior angina, prior myocardial infarction, prior cerebrovascular disease, peripheral arterial disease or microalbuminuria*, positive family history of coronary artery disease §); 5. Written informed consent. * Defined as >2.5-25 mg albumin/mmol creatinin for men and >3.5-35 mg for women, or >20-200 mg/l urinary albumin concentration in a single urine sample. § Angina pectoris, myocardial infarction, or sudden abrupt death without obvious cause, before the age of 55 in a first-degree blood relative.
Exclusion criteria
Exclusion criteria: 1. Myocardial ischemia precipitated by a condition other than atherosclerotic coronary artery disease (e.g. arrhythmia, severe anemia, hypoxia, thyrotoxicosis, cocaine abuse, severe valvular disease, hypotension); 2. Left ventricular ejection fraction < 30 % or end-stage congestive heart failure (NYHA class III or IV); 3. Renal dialysis or severe chronic kidney disease with measured or calculated GFR (Cockroft-Gault or MDRD4 formula) of < 30 ml/min/1.73 m2; 4. Co-existent condition with life-expectancy < 1 year or otherwise not expected to complete follow-up.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary endpoint is a composite of cardiovascular mortality or a clinical diagnosis of a non-fatal acute coronary syndrome during 1-year follow-up. | — |
Contacts
Public ContactR.M. Oemrawsingh
Outcome results
None listed