Chronic pancreatitis (CP).
Conditions
Interventions
1. Surgical drainage: pancreaticojejunostomy
2. Endoscopic drainage: ESWL and/or pancreatic stenting.
Sponsors
None listed
Eligibility
Inclusion criteria
Inclusion criteria: 1. A diagnosis of CP, based on clinical symptoms in combination with morphological changes established by imaging studies (calcifications or ductal changes) and/or pancreatic functional insufficiency; 2. A dominant obstruction of the Pancreatic Duct, demonstrated by presence of a stenosis and/or intraductal stones on MRCP and abdominal CT-scan, located left from the spine, with pre-stenotic ductal dilatation of at least 5 mm; 3. Severe recurrent pancreatic pain with insufficient relieve by non-narcotic analgesics or requiring opiates.
Exclusion criteria
Exclusion criteria: 1. Age below 18 or over 80 years; 2. Pancreatic head enlargement > 4 cm; 3. Contra-indication for surgery; ASA class 4, severe portal hypertension; 4. Contra-indications for endoscopy: gastrectomy with Billroth II reconstruction, other pancreatitis related complications (bile duct stricture, pseudocyst) requiring surgery; 5. Previous pancreatic surgery; 6. Suspected pancreatic malignancy; 7. Limited life expectancy (< 2 years); 8. Pregnancy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mean Izbicki painscore during follow-up. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Clinical success: pain relief at end of FU; 2. Complete (Izbicki pain score ¡Ü 10); 3. Partial (>50% decrease, total score > 10); 4. Morbidity and mortality rate; 5. Intervention rate; 6. Hospital stay; 7. Development of endo- and/or exocrine pancreatic insufficiency. | — |
Contacts
Public ContactDjuna Cahen
Academic Medical Center (AMC), P.O. Box 22660
Outcome results
None listed