Changes in vascular function after a reduced sitting intervention

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON27638

Enrollment

Registered

2017-04-12

Start date

2017-03-28

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

sedentary behaviour, reduced sitting, vascular function, cardiovascular risk

Interventions

Reduced sitting intervention: throughout the day participants prevent prolonged (i.e. >30 min) seated behaviour. This will be accomplished by a pedometer, which records physical activity levels. This

Eligibility

Inclusion criteria

Inclusion criteria: People who spend >40 hours per week sitting with an increased cardiovascular risk. An increased risk for cardiovascular disease was defined as those older than 45 years (men) or 55 (women) and presence of at least 1 cardiovascular risk factor.

Exclusion criteria

Exclusion criteria: Persons who are not physically able to perform light-intensity physical activity such as standing and walking.

Design outcomes

Primary

Measure	Time frame
The main parameter of this study is the change in vascular function, as is measured by superficial femoral artery FMD at baseline, before and after intervention. Improvements in vascular function are associated with reduced risk for future cardiovascular events (17). Endothelial function will be measured before and after a challenge of 3 hours continuous sitting and after a challenge of 3 hours sitting with short bouts of light intensity activity every 30 minutes. This challenge will be repeated after the intervention period to evaluate whether the effects an acute challenge of prolonged sitting is different after intervention.	—

Measure

Time frame

The main parameter of this study is the change in vascular function, as is measured by superficial femoral artery FMD at baseline, before and after intervention. Improvements in vascular function are associated with reduced risk for future cardiovascular events (17). Endothelial function will be measured before and after a challenge of 3 hours continuous sitting and after a challenge of 3 hours sitting with short bouts of light intensity activity every 30 minutes. This challenge will be repeated after the intervention period to evaluate whether the effects an acute challenge of prolonged sitting is different after intervention.

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Secondary

Measure	Time frame
Cerebral autoregulation will serve as secondary outcome. Change in cerebral autoregulation and cerebrovascular reactivity will be measured after a challenge of 3 hours continuous sitting and after a challenge of 3 hours sitting with short bouts of light intensity activity every 30 minutes. As an explorative aim, markers of inflammation NO synthesis, coagulation and adhesion properties, and levels of oxidative stress will be secondary parameters in all subjects. In addition, in all subjects physical fitness will be assessed as an explorative aim.	—

Measure

Time frame

Cerebral autoregulation will serve as secondary outcome. Change in cerebral autoregulation and cerebrovascular reactivity will be measured after a challenge of 3 hours continuous sitting and after a challenge of 3 hours sitting with short bouts of light intensity activity every 30 minutes. As an explorative aim, markers of inflammation NO synthesis, coagulation and adhesion properties, and levels of oxidative stress will be secondary parameters in all subjects. In addition, in all subjects physical fitness will be assessed as an explorative aim.

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Contacts

Public ContactYvonne Hartman

yvonne.hartman@radboudumc.nl+31 243613650

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)