LEOPARD: Longitudinal Evaluation Of a Predictive Algorithm for Response in Depression

Longitudinal evaluation of an MRI-based predictive algorithm for early assessment of treatment response in depression

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON27632

Enrollment

Registered

2020-09-08

Start date

2020-11-01

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Major Depressive Disorder

Interventions

Questionnaires and non-invasive MRI scanning.

Eligibility

Inclusion criteria

Inclusion criteria: Moderate or severe diagnosis of MDD based on a structured clinical interview (MINI) Score of >20 on the MADRS. Age 18-6

Exclusion criteria

Exclusion criteria: IQ of less than 70 as assessed by the Dutch national adult reading test (Nederlandse Leest-est voor Volwassenen (NLV)). Alcohol and/or drug dependence according to DSM-5 criteria. A history of skull fracture or a severe or disabling medical condition. Contraindications to MRI scanning Neurological comorbidity or major residual structural differences due to prior neurological pathology

Design outcomes

Primary

Measure	Time frame
Response or non-response defined as a greater than 50% reduction in MADRS score at week 8 when compared to baseline.	—

Secondary

Measure	Time frame
Response to treatment as a score of 1 or 2 on the Clinical Global Impression Scale (CGI) improvement item (indicating “very much improved ”or “much improved”) at week 8	—

Contacts

Public ContactMaarten Poirot

Amsterdam UMC

m.g.poirot@amsterdamumc.nl0622605934

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)