The effects of propranolol on fear of wisdom tooth removal: A randomized, placebo-controlled, double-blind, parallel design trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON27619

Enrollment

Registered

2010-07-01

Start date

2014-03-01

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dental phobia / Odontophobia / Specific phobia, blood-injection-injury type

Interventions

At day one: Third molar removal: 1. Propranolol 80 mg prior to, and 40 mg directly after treatment, or

2. Placebo 80 mg prior to, and 40 mg directly after treatment. At day 30: Third molar removal.

Eligibility

Inclusion criteria

Inclusion criteria: 1. Excessive anxiety for necessary third molar extraction; 2. Age above 18 years.

Exclusion criteria

Exclusion criteria: 1. Systolic blood pressure < 100mmHg; 2. Allergic asthma, Decompensatio cordis, Cardiac arrythmia or Insulin-dependent diabetes; 3. Previous adverse reaction to a beta-blocking agent; 4. Use of another beta-blocking agent; 5. Pregnant or breast feeding; 6. Being in psychotherapy elsewhere; 7. Renal failure.

Design outcomes

Primary

Measure	Time frame
- emotional intensity and vividness of traumatic memory - state anxiety - trait anxiety - heart rate, blood pressure	—

Secondary

Measure	Time frame
- PTSD-sympom severity and dental phobia	—

Contacts

Public ContactA. Jongh, de

Louwesweg 1

A.de.Jongh@acta.nl+31 (0)20 5188233

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)