Perioperative analgesia and postoperative pain processing

Effects of extended multimodal analgesia on early postoperative pain processing: A pilot study

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON27616

Enrollment

Registered

2008-03-01

Start date

2004-06-01

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Perioperative analgesia

Interventions

Verum: 48h continuous epidural analgesia at 5 ml/h of bupivacaine 0.25% with fentanyl 2 mcg/ml, 48h continuous S-ketamine infusion at 0.5 mcg/kg/min, 1 week diclofenac suppositories at 3x50mg Control

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients for elective abdominal surgery with indication for combined epidural and general anaesthesia

Exclusion criteria

Exclusion criteria: 1. Previous abdominal or thoracic surgery 2. Chronic pain syndrome 3. Chronic analgesic medication 4. Contraindication to epidural anaesthesia 5. Contraindications to S-ketamine or diclofenac 6. Major psychiatric disease 7. Inability to comprehend or participate in quantitative sensory testin

Design outcomes

Secondary

Measure	Time frame
Pain scores at rest and on movement, cold pressor test results, presence of chronic pain 6 months postoperatively	—

Primary

Measure	Time frame
Incidence of electrical and mechanical hyperalgesia on postoperative days 1 and 5	—

Contacts

Public ContactOliver H.G. Wilder-Smith

Department of Anaesthesiology Radboud University Nijmegen Medical Centre POB 9101

o.wildersmith@anes.umcn.nl+31 (0)24 3668120

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)