Inspiratory Muscle Training in Myotonic Dystrophy type 1: a pilot study.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON27599

Enrollment

Registered

2020-01-08

Start date

2020-04-01

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Myotonic Dystrophy type 1

Interventions

12 weeks program of IMT.

Eligibility

Inclusion criteria

Inclusion criteria: In order to be eligible to participate in this study, a subject must meet all of the following criteria: - Diagnosed with DM1 (based on DNA features). - Age = 18 years old. - Reduced PImax and vital capacity (both <80% of predicted). - Able to provide feedback.

Exclusion criteria

Exclusion criteria: A potential subject who meets any of the following criteria will be excluded from participation in this study: - Need or indication for HMV (daytime hypercapnia, pCO2 = 6.0 kPa) - Inability to adequately use a POWERbreathe, for example air leak during maneuvers. - Inability to communicate or answer questionnaires. - Vital capacity <25% of predicted. - Clinically unstable, for example pneumonia

Design outcomes

Primary

Measure	Time frame
inspiratory muscle strenght and inspiratory endurance capacity after 12 weeks of training.	—

Secondary

Measure	Time frame
Symptoms (using questionnaires about cough, dyspnea, quality of life, fatigue), lung volumes, gas-exchange during the nigth, effects on diaphragm using ultrasound and EMG.	—

Contacts

Public ContactCharlotte Seijger

UMCG

c.g.w.seijger@umcg.nl050 361 32 00

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)