Osteoporosis
Conditions
Interventions
None
Sponsors
HAN University of Applied Sciences
Eligibility
Inclusion criteria
Inclusion criteria: Inclusion criteria World tour level (highest level) professional male cyclists (aged 22 – 40): • Male • Professional cyclist competing in UCI’s WorldTour competition • Willing to give written informed consent. • Willing to comply with study procedures. • Accept use of all encoded data, including publication, and the confidential use and storage of all data for 15 years. World tour level professional female cyclists (aged 22 – 40): • Female • Professional cyclist competing in UCI’s Women’s WorldTour competition • Willing to give written informed consent. • Willing to comply with study procedures. • Accept use of all encoded data, including publication, and the confidential use and storage of all data for 15 years. Talented elite male cyclist (aged 18 – 22): • Male • Included in a talent program of professional cycling team • Willing to give written informed consent. • Willing to comply with study procedures. • Accept use of all encoded data, including publication, and the confidential use and storage of all data for 15 years. Retired world tour level professional cyclists (aged 35 – 60): • Retired male of female professional cyclist. • A minimum of 5 years of professional cycling at WorldTour level. • Duration of retirement is minimal 1 year before Day 01 of this study. • Willing to give written informed consent. • Willing to comply with study procedures. • Accept use of all encoded data, including publication, and the confidential use and storage of all data for 15 years.
Exclusion criteria
Exclusion criteria: Exclusion criteria • Having a history of medical events or medication use that may significantly affect bone metabolism, to be decided by the principal investigator. • Medication use that may affect tests within this study must be minimal 3 months before Day 01 of this study. • Participation in any clinical trial including blood sampling and/or administration of substances up to 30 days before Day 01 of this study • A recent injury that may significantly affect BMD, to be decided by the principal investigator.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Whole body and regional (lumbar spine and femoral hip) bone mineral content as determined by dual-energy X-ray absorptiometry (DXA). Cycling exercise volume during the preceding 12 months (for retired cyclists we obtain the average volume during a 5 year period in their career). Dietary intake (energy, macronutrients, calcium, vitamin D). Blood parameters of bone health: Procollagen type I N propeptide (P1NP), carboxy-terminal crosslinking telopeptide of type I collagen (CTX-I), calcitonine, parathyroid hormone (PTH), testosterone and oestrogen. Current and life time sports participation. | — |
Primary
| Measure | Time frame |
|---|---|
| Whole body and regional (lumbar spine and femoral hip) bone mineral density (t- and z-scores) and bone mineral content as determined by dual-energy X-ray absorptiometry (DXA). | — |
Contacts
Public ContactLuuk Hilkens
HAN University of Applied Sciences
Outcome results
None listed