Reward mechanisms, mood and motivational symptoms in Parkinson's disease: an experimental approach.

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON27566

Enrollment

Registered

2007-11-05

Start date

2007-12-01

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Parkinson's disease (NLD: De ziekte van Parkinson).

Interventions

All subjects receive a 10 mg methylphenidate challenge, a 500 ìg pramipexole challenge and a placebo condition.

Eligibility

Inclusion criteria

Inclusion criteria: 1. Idopathic Parkinson's disease; 2. Informed consent.

Exclusion criteria

Exclusion criteria: 1. Other concurrent neurological diseases than PD; 2. Concurrent psychiatric disease; 3. Use of psychopharmacological medication; 4. Abuse of alcohol and drugs; 5. Cognitive deterioration as operationalized by a score of <23 on the MMSE; 6. Use of levodopa preparations of dopamine agonists.

Design outcomes

Primary

Measure	Time frame
Main study parameters are the performance on neuropsychiatric and neuropsychological tests for both groups, including assessments of cognitive status, mood, apathy, and an observation of spontaneous self-reward behaviour.	—

Contacts

Public ContactR.L. Drijgers

Brain & Behaviour Institute Maastricht University, DOT 12 Postbus 616

rosa.drijgers@np.unimaa043-3881839

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)