Microbiome (microbioom) Healthy infant (gezond kind) Delivery mode (partus)
Conditions
Interventions
Observational prospective cohort study. The development of the infant microbiome during the first 12 months of life and the potential differences in the microbial composition between infants born vagi
Sponsors
Wetenschapsbureau Linneaus instituut Hoofddorp
Eligibility
Inclusion criteria
Inclusion criteria: 1. Term neonates; 2. Born in the region of Groot Kennemerland and bollenstreek (draining on Spaarne hospital Hoofddorp or Kennemer Gasthuis Haarlem).
Exclusion criteria
Exclusion criteria: 1. Severe perinatal/ neonatal/ maternal complications as asphyxia, resuscitation, transfer to neonatal intensive care unit etc; 2. Major congenital anomalies; 3. Language barrier; 4. Intention to move outside the research area; 5. Parents under the age of 18 years.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Comparison of the composition of infant microbiome between infants born vaginally and infants born by caesarean section at several time points during the first 12 months of life; 2. The dynamics of the infant nasopharyngeal and oral microbiome in periods of respiratory infections. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. The relation between nasopharyngeal, oral, gastrointestinal and skin microbiome; 2. The dynamics of the infant microbiome in periods of antibiotic consumption; 3. Comparison of the composition of the maternal microbiome and the infant microbiome; 4. Comparison of the composition of the infant microbiome between breastfed infants and formula fed infants; 5. The dynamics of the infant microbiome in case of eczema/atopic diseases; 6. The dynamics of the infant microbiome related to exposure (siblings, day care). | — |
Contacts
Public ContactAstrid Bosch
WKZ / Spaarne Ziekenhuis / Kennemer Gasthuis Postbus 770
Outcome results
None listed