Perioperative antibiotic use in the treatment of acute inflammation of the gallbladder.

Perioperative antibiotic use in the treatment of acute calculous cholecystitis.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON27470

Enrollment

158

Registered

2011-09-29

Start date

2012-01-01

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute calculous cholecystitis (Dutch: Acute calculeuze cholecystitis)

Interventions

1. Extended postoperative antibiotic prophylaxis (cefuroxime 750 mgs 3dd & metronidazole 500mgs 3dd during 72 hours)

2. Postoperative clinical observation.

Eligibility

Inclusion criteria

Inclusion criteria: 1. Acute calculous cholecystitis; 2. APACHE-II score 1-6; 3. Written informed consent.

Exclusion criteria

Exclusion criteria: 1. < 18 years of age; 2. APACHE-II score ≥ 7; 3. Already receiving antibiotics prior to diagnosis; 4. Proven allergy to Cefuroxime/ Metronidazole; 5. Pregnancy.

Design outcomes

Primary

Measure	Time frame
All infectious complications.	—

Secondary

Measure	Time frame
1. Individual components of composite endpoint; 2. All other complications; 3. Total length of hospital stay; 4. Total direct and indirect costs.	—

Contacts

Public ContactD. Boerma

St Antonius Hospital, Department of Surgery, P.O. Box 2500

djamilaboerma@hotmail.com

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)