Peripheral arterial disease
Conditions
Interventions
None listed
Sponsors
UMCG
Eligibility
Inclusion criteria
Inclusion criteria: Healthy volunteers: - 18 years and older - Written informed consent - Rutherford classification 0 Patients with PAD: - 18 years and older - Written informed consent - Claudicants, Rutherford classification 2 and 3. - Chronic limb-threatening disease, Rutherford classification 4 to 6
Exclusion criteria
Exclusion criteria: Healthy volunteers: - Investigations or treatment for cardiovascular disease - Symptoms or history of peripheral neuropathy Both healthy volunteers and patients with PAD: - Insufficient knowledge of the Dutch language, illiteracy or language barrier - Concurrent uncontrolled medical conditions - Lower leg fractures within the past 12 months. - (Partial) amputation of one of the feet and/or legs. - Pregnant or breast feeding. - Severe peripheral oedema. - Severe cardiac-pulmonary failure. - Active cellulitis-erysipelas of the legs or other dermatological diseases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To develop a standardized and optimized measurement protocol for EPOS measurements, including location on the lower leg, to optimize precision and accuracy of measurements. | — |
Secondary
| Measure | Time frame |
|---|---|
| The second objective is to correlate hemoglobin oxygen saturation(%), red blood cell tissue fraction (%) and the speed resolved RBC perfusion separated into three speed regions; 0-1 mm/s, 1-10 mm/s and above 10 mm/s (% mm/s) with TcPO2 in healthy volunteers, claudicants and patients with chronic limb-threatening ischemia. | — |
Contacts
Public ContactKirsten Ma
UMCG
Outcome results
None listed