RBP4 and glucose metabolism.

The role of RBP4 in human glucose metabolism.

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON27408

Enrollment

Registered

2013-02-03

Start date

2013-02-04

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obesity Insulin resistance Type 2 diabetes mellitus

Interventions

None listed

Eligibility

Inclusion criteria

Inclusion criteria: 1. Female; 2. BMI > 35 kg/m2; 3. Age between 26 and 50 years; 4. Established T2DM.

Exclusion criteria

Exclusion criteria: 1. Primary lipid disorder or secondary lipid disorder treated with fibrates; 2. T2DM treated with thiazolidinediones, DPP4-inhibitors or GLP1-analogues; 3. Any medical condition except for glucose intolerance, hypertension and secondary dyslipidemia; 4. Bleeding disorder; 5. Untreated primary hypothyroidism; 6. Contra-indications for MR scanning.

Design outcomes

Primary

Measure	Time frame
Circulating and tissue levels of RBP4, in relation to: 1. Endogenous glucose production; 2. Hepatic, peripheral and adipose tissue insulin sensitivity; 3. Hepatic triglyceride content.	—

Secondary

Measure	Time frame
Correlation levels of RBP4 with hepatic enzymes involved in gluconeogenesis.	—

Contacts

Public ContactMurat Kilicarslan

m.kilicarslan@amc.uva.nl+31 (0)20 5663507

Outcome results