Obesity (according to the international criteria of Cole et al (2000)
Conditions
Interventions
Functional MRI consists of a resting state measurement and an passive image paradigm. These images are in the category of healthy and unhealthy food and non-food images.
Sponsors
Prof.dr.H.A.Delemarre-van de Waal
Prof. of Pediatrics
Head Dep. Pediatics
LUMC University Hospital Leiden
P.O.Box 9600
2300RC Leiden
The Netherlands
0031715262824
Eligibility
Inclusion criteria
Inclusion criteria: Cases and controls: 1. Male (n=10) and female (n=10); 2. Participant in the age group 12-16 years. Cases: 1. Obesity according Cole (2000). Controls: 1. Weight between + and - 1 SD.
Exclusion criteria
Exclusion criteria: Cases: 1. Overweight caused by a medical problem (determined by our standard protocol); 2. Weight loss in the three months prior to the study. Cases and controls: 1. Claustrophobia; 2. Behavioural or emotional problems; 3. Mental retardation; 4. Vision problems (determined anamnestic); 5. Participants with any special diet (e.g. a vegetarian diet); 6. Wearing of metal objects that cannot be removed (braces, piercing).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Structural measurements of neural structures involved in eating behavior (amygdala, nucleus accumbens, hippocampus, insula) in obese and non-obese adolescents; 2. Neuronal responses in a resting state condition in obese and non-obese adolescents; 3. Neuronal responses to food stimuli (eg prefrontal cortex) in obese and non obese adolescents. | — |
Contacts
Public ContactC.J. Groot, de
Albinusdreef 2
Outcome results
None listed