Reversal of morphine and morphine-6-glucuronide's respiratory effect by naloxone: A clinical study in healthy volunteers.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON27397

Enrollment

Registered

2005-09-06

Start date

2005-01-01

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Measurement of respiration on a breath-to-breat basis. We will study 4 groups, with 12 subjects per group. - Group I will receive M6G 0.2 mg/ kg, - Group II M6G 0.4 mg/kg, - Group III morphine 0.15

Eligibility

Inclusion criteria

Inclusion criteria: 1. Healthy volunteers 18+.

Exclusion criteria

Exclusion criteria: 1. Obesity (BMI > 30); 2. Presence of medical disease (heart-, lung-, liver-, kidney-, neurological disease; diabetes m.; pyrosis; diaphragmatic hernia); 3. Presence of psychiatric disease; 4. History of chronic alcohol or drug use; 5. Allergy to study medications; 6. Possibility of pregnancy; and 7. Lactating females.

Design outcomes

Primary

Measure	Time frame
Minute ventilation and pain response to heat pain.	—

Contacts

Public ContactAlbert Dahan

Leiden University Medical Center (LUMC), Department of Anesthesiology, P.O. Box 9600

a.dahan@lumc.nl+31 (0)71 5262301

Outcome results