None listed
Conditions
Interventions
Ventilatory response to isocapnic hypoxia:
What is the effect of a clinical oral dose of acetazolamide on the isocapnic hypoxic response (IHR), i.e. an exposure to hypoxia (end-tidal PO2 ~ 5.8 kPa) du
Sponsors
Leiden University Medical Center
Eligibility
Inclusion criteria
Inclusion criteria: 1. Healthy volunteers aged 18-45 years
Exclusion criteria
Exclusion criteria: 1. Obesity (BMI > 30) 2. Presence of medical disease (heart-, lung-, liver-, kidney- and logic disease; diabetes M.) 3. Presence of psychiatric disease 4. History of chronic alcohol or drug use 5. Allergy to study medications 6. Possibility of pregnancy 7. Lactation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Comparisons that will be made Hypoxic responses at alkalosis (placebo + bicarbonate), acidosis (acetazolamide) and normal pH (placebo as well as acetazolamide + bicarbonate) Hypoxic responses at normal pH: placebo versus acetazolamide + bicarbonate. Hypoxic responses: effect of acetazolamide on isocapnic versus poikilocapnic hypoxic ventilatory response. A-aDO2 gradients and arterial O2 saturations at various pH’s without and with acetazolamide. | — |
Contacts
Public ContactJan Ramshorst, van
Leiden University Medical Center (LUMC) Department of Cardiology Postal zone: C5-P P.O. Box 9600
Outcome results
None listed