Comparison between immune response to different modes of vaccination; intradermal and subcutaneous yellow fever vaccination.

Comparison between immune response to different modes of vaccination; antibody response to intradermal and subcutaneous yellow fever vaccination, measured by ELISA, IF and plaque reduction assay.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON27364

Enrollment

120

Registered

2005-09-06

Start date

2005-06-15

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

(Prevention of) yellow fever.

Interventions

Subcutaneous of intradermal yellow fever vaccination.

Eligibility

Inclusion criteria

Inclusion criteria: Healthy volunteers, >18yrs (previously and not previously vaccinated with yellow fever vaccine).

Exclusion criteria

Exclusion criteria: 1. Pregnancy; 2. Diabetes mellitus; 3. Use of immunomodulating medication e.g. corticosteroids; 4. Cytostatica; 5. Use of chloroquine.

Design outcomes

Primary

Measure	Time frame
Protective humoral immune response. For first time vaccinees measured 4 and 8 weeks post-vaccination, for revaccinees measured 2 weeks post-vaccination. All sera will be analysed by ELISA, Immunofluorescence and plaque reduction assay.	—

Secondary

Measure	Time frame
Adverse events measured for three weeks post-vaccination by keeping a diary, viremia measured 5 days post-vaccination by RT-PCR.	—

Contacts

Public ContactA.H.E. Roukens

Leiden University Medical Center (LUMC), P.O. Box 9600

a.h.e.roukens@lumc.nl

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)