Influence of the dietary history in the prevention of coeliac disease: possibilities of induction of tolerance for gluten in genetic predisposed children.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON27354

Enrollment

1000

Registered

2007-02-08

Start date

2007-01-01

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

coeliac disease (coeliakie)

Interventions

In the family study: 1. The ‘intervention group’ will get a small amount of gluten (1 gram of wheat flour= 100mg gliadin) during the period of breastfeeding from the age of 4 months for 8 weeks. 2. Th

Eligibility

Inclusion criteria

Inclusion criteria: 1.Infant born during the study with a first degree relative (parent or sibling) with CD; 2.Informed consent for the study.

Exclusion criteria

Exclusion criteria: 1. No informed consent; 2. Parents-guardians unable to understand the information necessary to give informed consent.

Design outcomes

Primary

Measure	Time frame
A reduction of 50% of CD among the intervention group at the age of 3 years will be considered as an effective prevention.	—

Secondary

Measure	Time frame
If the proposed early dietary intervention results in effective prevention of CD: 1. Development of new European guidelines for early nutrition in order to prevent the disease; 2. Identification of the influence of early feeding on the development of coeliac disease in relation with immunological and genetical factors.	—

Contacts

Public ContactM.L. Mearin

Leiden University Medical Centre Dept. Of Pediatrics PO box 9600

M.L.Mearin_Manrique@lumc.nl-

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)