Sentinel node biopsy (SNB), sentinel lymph node (SLN), oral cancer, magnetic detection. DUTCH: poortwachterklier procedure, mondholte kanker, magnetische detectie
Conditions
Interventions
Peritumoral injection of SPIO, after Xillocaïne spray, and followed by an MRI to localize the SLN, the day before surgery. Also trancutaneous detection of trapped SPIO in SLN will be performed using a
Sponsors
University of Twente
Eligibility
Inclusion criteria
Inclusion criteria: - Patients diagnosed with T1-T2 oral cancer scheduled for END and who have clinically and radiologically at maximum cN1, <15mm and not contains necrotic tissue; - Willing to & able to write informed consent from the subject prior to participation. - Willing to & capable of following study procedures - Is older than 18 years - Speaks and understand the Dutch language
Exclusion criteria
Exclusion criteria: - Positive result of ultrasound fine needle aspiration, for nodes >15mm and/or necrotic tissue; - Intolerance/ hypersensitivity to iron or dextran compounds or Sienna+; - Intolerance/ hypersensitivity to lidocaine; - Patients with an iron overload disease; - Patients with non-palpable malignancies; - Pregnant patients; - Patients with pacemakers or other implantable devices in the upper body.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To investigate the feasibility of the magnetic approach in detection of the SLNs during SNB in the neck of patients with T1-T2 cancer | — |
Secondary
| Measure | Time frame |
|---|---|
| - Detectionrate - Compare results of MRI, surgery and pathology. | — |
Contacts
Public ContactE.R. Nieuwenhuis
Magnetic Detection & Imaging group, University of Twente
Outcome results
None listed