Aging
Conditions
Interventions
Balance training on an unstable surface, cycling on an a stationary bicycle ergometer and no-intervention control
Sponsors
University Medical Center Groningen
Eligibility
Inclusion criteria
Inclusion criteria: Young adults: Age between 18 and 40, female or male, healthy. Old adults: Age between 65 and 85, female or male, healthy.
Exclusion criteria
Exclusion criteria: A score lower than 24 on the Mini Mental State Examination A score higher than 70 on the falls self-efficacy scale More than 1 fall over the past year (‘Coming unintentionally to rest on the ground, floor, or lower level’) Do not meet TMS guidelines Unable to stand independently for 10 minutes without rest Epilepsy Any metal in the brain/skull Electrical, magnetic, or mechanical implantation: cardiac pacemakers or intracerebral vascular clip Pregnancy or suspicion of pregnancy History of seizures or unexplained loss of consciousness Immediate family member with epilepsy Use of seizure threshold lowering medicine History of Schizophrenia History of Hallucinations History of other neurological disorders A prior stroke, heart attack, heart failure, bypass, cardiac arhythmia Acute flu or cold Spinal, joint, and head pain Diabetes mellitus Hypertension (systolic/diastolic > 160/ > 100 mmHg) Acute and chronic inflammatory condition Severe arthrosis Vertigo Knee or hip endoprosthesis Trauma within the last 6 months Active cancer, cancer therapy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Behavioral outcome during balance learning is the error produced by balancing on an unstable balance board (Sensamove, Groessen, NL). The error, in degrees, is computed as the cumulative deviation between the position of the board relative to the horizontal. In addition to the performance on the balance board, the laboratory behavioral outcome is the magnitude of sway on the force platform measured in standing with a narrow stance during TMS and EEG testing. Magnitude of sway is expressed in cm as path length over unit time and the velocity of sway in the anterior-posterior and in the medio- lateral directions. | — |
Secondary
| Measure | Time frame |
|---|---|
| TMS outcomes include the size of the short-interval intracortical inhibition (SICI), long- interval intracortical inhibition (LICI), and corticospinal excitability measured as the amplitude of the motor evoked potential (MEP). EEG outcomes include the phase slope index, a measure of connectivity in the frequency domain between specific brain areas. | — |
Contacts
Public ContactLisanne Bakker
Outcome results
None listed