COPD
Conditions
Interventions
The multidisciplinary outpatient pulmonary rehabilitation program consists of a 10-week training program with 2 hour sessions, 3 times a week. The pulmonary rehabilitation program also includes educat
Sponsors
Radboud University Nijmegen Medical Centre, Department of Pulmonary diseases
Eligibility
Inclusion criteria
Inclusion criteria: 1. Stable COPD GOLD I-III; 2. Dynamic hyperinflation during ADL.
Exclusion criteria
Exclusion criteria: 1. Long term oxygen therapy at home; 2. Severe ADL-limiting cardiac or neuromuscular disease; 3. Co-existing lung disease other than COPD; 4. Other inflammatory diseases; 5. Treatment with systemic anti-inflammatory drugs; 6. Previous participation in rehabilitation program (<2 year). Extra exclusion criterium for control COPD patients: 1. Participation in supervised physical therapy program.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Dynamic hyperinflation; 2. Dyspnea; 3. Biomarkers of systemic inflammation after ADL. Dynamic hyperinflation and other respiratory impairments during ADL will be measured using the Oxycon Mobile (Viasys Healthcare, Germany), which is a portable breath-by-breath system, consisting of a face mask with turbine volume transducer and integrated O2 and CO2 gas analyzers. Subjects will be asked to rate their shortness of breath using a 10-point Borg scale at start and end of each ADL. Systemic inflammation will be characterized by measuring the number of circulating leukocytes (standard laboratory tests), and plasma levels of interleukins. | — |
Contacts
Public ContactL.M. Willems
UCCZ Dekkerswald, 4611
Outcome results
None listed