Gastrointestinal tolerance in healthy volunteers in which gastric conditions of critically ill patients will be mimicked by medication.
Conditions
Interventions
Duration of intervention: 4 hours
Intervention product: whey dominant tube feed
Control product: casein dominant tube feed
Sponsors
Nutricia Research B.V.
Uppsalalaan 12,
3508 CT Utrecht – the Netherlands
Eligibility
Inclusion criteria
Inclusion criteria: Main inclusion criteria 1. Age between 18 and 50 (including 18 and 50) years 2. Being in good health as to the judgement of the investigator 3. Written informed consent
Exclusion criteria
Exclusion criteria: Main exclusion criteria 1. Known history of any disorders such as; gastrointestinal (GI), cardiovascular, respiratory, hematological, renal, hepatic, hypothyroidism, psychiatric panic attacks and/or diabetes mellitus and/or a history of brain tumor, an enlarged prostate or urination problems and/or recent head injury 2. Presence of implants, devices, or metallic foreign bodies interacting with MRI 3. A low systolic blood pressure (<100 mm Hg) in supine position 4. Pregnancy or breastfeeding
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Gastric content volume | — |
Secondary
| Measure | Time frame |
|---|---|
| Plasma amino acid concentrations | — |
Contacts
Public ContactPeter van Horssen
PO box. 80141
Outcome results
None listed