Healthy volunteers
Conditions
Interventions
LSD (20 µg) and to placebo
Sponsors
Maastricht University
Eligibility
Inclusion criteria
Inclusion criteria: • Written Informed Consent • Understanding the procedures and the risks associated with the study. • At least 18 years of age • Absence of any major medical condition as determined by medical examination and laboratory analysis • Absence of any major psychological condition as determined by medical examination • Free from psychotropic medication • Participants must be willing to refrain from taking illicit psychoactive substances during the study. • Participants must be willing to drink only alcohol-free liquids and no coffee, black or green tea, or energy drink after midnight of the evening before the study session, as well as during the study day. • Participants must be willing not to drive a traffic vehicle or to operate machines within 24 h after substance administration. • Participants are asked to not make any substantial changes in their diet. • Participants must be willing to comply with guidelines regarding their bedtime. • Normal weight, body mass index (weight/height2) between 18 and 28 kg/m2
Exclusion criteria
Exclusion criteria: • History of drug addiction (determined by the medical questionnaire, drug questionnaire and medical examination) • Previous experience of serious side effects to psychedelic drugs (anxiety or panic attacks) • Pregnancy or lactation • Hypertension (diastolic > 90 mmHg; systolic > 140 mmHg) • Current or history of psychiatric disorder (determined by the medical questionnaire and medical examination) • Psychotic disorder in first-degree relatives • Any chronic or acute medical condition • History of cardiac dysfunctions (arrhythmia, ischemic heart disease,…) • For women: no use of a reliable contraceptive • Tobacco smoking (>20 per day) • Excessive drinking (>20 alcoholic consumptions per week) • Experience with a full dose of a psychedelic within the last three months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary objective is to investigate the effects of three repeated morning vs evening doses of LSD (20 µg) on mood. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary objectives are to investigate the effects of three repeated morning vs evening doses of LSD (20 µg) on neuroplasticity, sleep parameters, cognitive performance measures, emotion regulation, markers of well-being, cortisol, and endocannabinoid levels. | — |
Contacts
Public ContactEline Haijen
Maastricht University
Outcome results
None listed