gastric premalignant lesions, intestinal metaplasia voorstadia maagkanker, intestinale metaplasie
Conditions
Interventions
: Patients will be evaluated on separate occasions using standard white-light endoscopy plus random biopsies (current diagnostic strategy) and the using enhanced endoscopic imaging with targeted biops
Sponsors
Erasmus University Medical Center
Eligibility
Inclusion criteria
Inclusion criteria: 1. All patients referred to the endoscopy department for an upper gastrointestinal endoscopy for investigation of symptoms, screening or surveillance, who are found to have chronic atrophic gastritis between November 2018 and May 2020. 2. Patients will be over the age of 18 years old. 3. Patients must be able to give informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients with gastric neoplasia not amenable to endoscopic resection 2. Patient who do not have an indication for Sydney biopsy staging on standard WLE 3. Patients with significant comorbidities 4. Patients with coagulation disorders 5. Patients with previous gastric surgery 6. Being unable to complete the biopsy protocol on either endoscopy session
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. The diagnostic accuracy for the endoscopic diagnosis of intestinal metaplasia in Sydney biopsy locations | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Reproducibility of endoscopic staging after expert review 2. Reproducibility of histopathology for detection of intestinal metaplasia 3. Number of dysplastic or neoplastic lesions detected 4. Longer inspection time of gastric mucosa increases accuracy | — |
Contacts
Public ContactS.A.V. Nieuwenburg
Outcome results
None listed