breast cancer, sentinel lymph node procedure, image-guided surgery, schildwacht klier procedure, borstkanker
Conditions
Interventions
Patients with operable breast cancer stage I-II undergoing a lumpectomy, combined with a sentinel lymph node procedure, will receive prior to a lumpectomy and SLN procedure an intratumoral injection w
Sponsors
University Medical Center Groningen, Department of Surgery
Eligibility
Inclusion criteria
Inclusion criteria: Patient with operable stage I-II breast cancer diagnosed preoperatively by core biopsy or cytology (cT1-2N0).
Exclusion criteria
Exclusion criteria: 1. Refusal of the patient to be included in the study; 2. Pregnant or breast-feeding; 3. Significant renal dysfunction (serum creatinine above 400 micromol/L); 4. cardiac and/or pulmonary disease (ASA III-IV); 5. History of iodine allergy or anaphylactic reactions to insect bites or medication; 6. Presence or history of hyperthyroidism; 7. Recent surgery on the armpit.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Whether ICG enhanced NIRF imaging is able to detect sentinel lymph nodes as good as or better than the standard technique (technetium-99 labelled colloid and Patent Blue) during breast surgery in 97%± 2% of the cases. | — |
Secondary
| Measure | Time frame |
|---|---|
| The number of lymph nodes detected by ICG enhanced NIRF imaging during breast surgery. | — |
Contacts
Public ContactG.M. Dam, van
University Medical Center Groningen Department of Surgery / BioOptical Imaging Center Groningen
Outcome results
None listed