Multiple sclerosis (MS), Cognitive problems
Conditions
Interventions
Cognitive rehabilitation therapy (CRT) and mindfulness-based cognitive therapy (MBCT).
Control condition: enhanced treatment as usual (ETAU).
Sponsors
VU University Medical Center
Eligibility
Inclusion criteria
Inclusion criteria: Participants are eligible to participate if they meet the following criteria: (1) between 18 and 65 years of age, (2) confirmed MS according to the McDonald 2010 criteria, (3) a minimum score of 23 on the Multiple Sclerosis Neuropsychological Questionnaire – Patient version (MSNQ-P), which measures subjective cognitive complaints.
Exclusion criteria
Exclusion criteria: Participants who meet any of the following criteria are excluded from participation: (1) psychosis, (2) suicidal ideation, (3) an inability to speak or read Dutch, (4) previous experience with a similar intervention, (5) physical or cognitive disabilities, comorbidities or treatments that would interfere too much with the interventions to enrol in this study (to be evaluated on an individual level).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Subjective cognitive complaints | — |
Secondary
| Measure | Time frame |
|---|---|
| - Objective cognitive function (neuropsychological examination based on the Minimal Assessment of Cognitive Function in MS (MACFIMS)), - Functional brain networks (magnetoencephalography (MEG)), - Psychological symptoms (depression, anxiety, fatigue, rumination), - Quality of life, - Well-being (the ability to be mindful, self-compassion, and emotional, psychological and social well-being), - Daily life functioning. | — |
Contacts
Public ContactI.M. Nauta
VU University Medical Center
Outcome results
None listed