Multiple Sclerosis is the most common immuun mediated inflammatoire demyelinisating disease of the central nervous system. In this study we focus on the progressive form of MS, primary as well as the secondary form. In these forms patients experience a progressive and chronical decline. In time they get more and more handicapped by their disease. The treatment of progressive MS remains an enormous challenge. Research has shown sometimes a temporary, no or barely significant on stabilizing the pr
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: Inclusion criteria group 1 with IVIG: - Patients with SPMS or PPMS according to the MacDonald criteria - Male and female - IVIG treatment ¡Ý 12 months Inclusion criteria group 2 without IVIG: - Patients with SPMS or PPMS according to the MacDonald criteria - Male and female - No IVIG treatment
Exclusion criteria
Exclusion criteria: Exclusion criteria group 1 with IVIG: - Patients with RRMS or PRMS - Therapie with other disease modifying drugs for MS - Pregnancy or labour < 1 year ago Exclusion criteria group 2 without IVIG: - Patients with RRMS or PRMS - Therapie with other disease modifying drugs for MS - Pregnancy or labour < 1 year ago - Use of IVIG in the last 2 years
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Quality of life and fatigue measured with questionnaires. | — |
Secondary
| Measure | Time frame |
|---|---|
| EDSS score. | — |
Contacts
Postbus 5500