glucose metabolism, lipid metabolism, RNA expression, anthropometrics, body composition, blood pressure, cognitive functioning, physical functioning, resting metabolic rate, depression, quality of life, sleep, hunger and appetite
Conditions
Interventions
3 months (13 weeks) intervention with 25% lowered energy expenditure, of which half (12.5% of energy) through caloric restriction and the other half through an increase in physical activity.
Partners
Sponsors
Leiden University Medical Center and Wageningen University
Eligibility
Inclusion criteria
Inclusion criteria: 1. Middle-aged (≤75 years) couples consisting of offspring from long-lived siblings and his/her current partner or in incidental case as single participant; 2. BMI ≥23 and ≤35 kg/m2.
Exclusion criteria
Exclusion criteria: 1. Type I or type II diabetes (on diabetic medication); 2. Individuals who have lost or gained ≥3 kg over the past 6 months; 3. Individuals engaged in heavy/intensive physical activity (top sport or physically heavy work); 4. Any disease or condition that seriously affects body weight and/or body composition including active types of cancer, heart failure (NYHA III/VI), COPD (GOLD III/VI); 5. Recent (3 months prior to intervention) immobilisation for longer than 1 week; 6. Psychiatric or behavioural problems (eg, history or clinical manifestation of any eating disorders, vegan dietary lifestyle, major depression); 7. Medication: thyroid medication, immunosuppressive drugs (e.g. prednisone, methotrexat, biologicals (TNF-alpha antagonists etc); 8. Concurrent participation in any other intervention study or weight management program; 9. Exclusion for biopsy: use of anticoagulantia (e.g. coumarines, carbaspirin calcium); 10. Exclusion MR imaging (7 tesla): A. Claustrophobia; B. Pacemakers and defibrillators; C. Nerve stimulators; D. Intracranial clips; E. Intraorbital or intraocular metallic fragments; F. Cochlear implants; G. Ferromagnetic implants (e.g. thoracic implant for scoliosis); H. Inability to lie supine during for 45 minutes; I. not having a general practitioner
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in fasting insulin level. | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood parameters (metabolic/metabolomics), parameters measured in biopsies of muscle and fat (transcriptomics/proteomics/epigenetics), anthropometrics, body composition, blood pressure, 24-hour glucose monitoring, energy metabolism (resting metabolic rate), MR imaging (leg, brain, cartilage of the knee) and psychological factors (cognitive performance, mood, quality of life, sleep, hunger). | — |
Contacts
Public ContactOndine Rest, van de
Wageningen University, Division of Human Nutrition P.O. Box 8129
Outcome results
None listed